Patents

Evolutionary Chemistry™ Selection

U.S. 5,723,289
U.S. 5,723,592
U.S. 5,789,160
U.S. 5,858,660
U.S. 6,030,776
U.S. 6,048,698

Modified RNA

U.S. 5,719,273 Palladium Catalyzed Nucleoside Modifications - Methods Using Nucleophiles and Carbon Monoxide.

U.S. 5,945,527 Palladium Catalyzed Nucleoside Modifications - Methods Using Nucleophiles and Carbon Monoxide.

Chemical Library Assembly

U.S. 5,659,069 Methods for the Cyclotrimerization of Alkynes in Aqueous Solution, Bruce Eaton and Matthew Sigman.

U.S. 5,760,266 Methods for the Cyclotrimerization of Alkynes in Aqueous Solution, Bruce Eaton and Matthew Sigman.

Publications

RNA Catalysts

RNA Diels-Alderases: Relationships Between Unique Sequences and Catalytic Function, Tarasow, T. M.; Tarasow, S. L.; Eaton, B. E. J. Am. Chem. Soc. 2000, 122, 1015.

Characteristics of an RNA Diels-Alderase Active Site, Tarasow, T. M.; Tarasow, S. L.; Tu, C.; Kellogg, E.; Eaton, B. E. J. Am. Chem. Soc. 1999, 121, 3614.

Dressed For Success: Realizing the Catalytic Potential of RNA, Tarasow, T. M.; Eaton, B. E. Biopolymers 1998, 48, 29.

RNA Catalysed Carbon-Carbon Bond Formation, Tarasow, T. M.; Tarasow, S. W.; Eaton, B. E. Nature 1997, 389, 54.

Selection of RNA Amide Synthases, Wiegand, T. W.; Janssen, R. C.; Eaton, B. E. Chem. Biol. 1997, 4, 675.

Modified RNA

The Joys of In Vitro Selection: Chemically Dressing Oligonucleotides to Satiate Protein Targets, Eaton B. E. Curr. Opin. Chem. Biol. 1997, 1, 120.

The RNA World: Functional Diversity in a Nucleoside by Carboxamidation of Uridine, Dewey, T. M.; Zyzniewski, C.; Eaton, B. E. Nucleosides & Nucleotides 1996, 15, 1611.

Palladium Catalysis in the Synthesis of 8-Position Modified Adenosine, 2'-Deoxyadenosine and Guanosine, Tu, C.; Keane, C.; Eaton, B. E. Nucleosides Nucleotides 1995, 14, 1631.

New Uridine Derivatives for use in Systematic Evolution of RNA Ligands by Exponential Enrichment, Dewey, T. M.; Mundt, A. A.; Crouch, G. J.; Zyzniewski, M. C.; Eaton, B. E. J. Am. Chem. Soc.. 1995, 117, 8474.

Ribonucleosides and RNA, Eaton, B. E.; Pieken, W. A. Annu. Rev. Biochem. 1995, 64, 837.

Structural Deconvolution of Combinatorial Oligonucleotide Libraries by Electrospray Mass Spectrometry Sequencing, Pomerantz, S. C.; Tarasow, T. M.; Eaton, B. E.; McCloskey, J. A. J. Am. Chem. Soc. 1997, 117, 3861.

Chemical Library Assembly

Cobalt Catalyzed Cyclotrimerization of Alkynes in Aqueous Solution, Sigman, M. S.; Fatland, A. W.; Eaton, B. E. J. Am. Chem. Soc. 1998, 120, 5130.

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